Acyl-Glutathione ($175) quickly earned a place in my skin-care routine. I like everything about it, except its small size, one fluid ounce. I want Dr. Perricone to super-size it.
Acyl-Glutathione (pronounced ay-sil gloo-ta-thigh-on), addresses the accelerated signs of aging, including severe dryness, extreme loss of elasticity, deep lines and wrinkles, and fragile, thin skin. Used as both a preventative and corrective moisturizer, this treatment helps create visibly improved skin in just 30 days. I've been using it for a few months and can report that it's effective.
I learned on Sephora's blog that the name, Acyl-Glutathione, comes from the patent-pending molecule created to replenish glutathione, an antioxidant, in our skin cells. If you experience a decrease in glutathione, your skin could appear fatigued, wrinkled, and/or dehydrated, or change in texture. Acyl-Glutathione works to fix those deficits by bringing your skin back to life and defying aging. After just 30 days of continued use (just a dime-sized amount, twice a day, says Perricone), you’ll notice a decrease in the appearance of fine lines, creases, and wrinkles and a boost in hydration.
In a 30-day consumer research study, after application every morning and evening:
- 85% saw a reduction in the appearance of horizontal forehead creases;
- 90% saw a reduction in the appearance of 11 vertical creases;
- 85% saw a reduction in the appearance of smile creases; and
- 88% saw a reduction in the appearance of marionette creases above the chin, but below the mouth.
The lightweight cream absorbs very quickly, leaving behind a protective "film" that's barely perceivable (I like to be able to feel my treatment moisturizer to know it's still there). The ingredients that contribute to its effectiveness include DMAE, glycolic acid, peptides, dimethicone, sesame seed oil, glycerin, and, unfortunately, the ubiquitous propylene glycol. I can't seem to shake that ingredient from my beauty products. The treatment is paraben-free.
Dr. Perricone recommends following the application of Acyl-Glutathione with a moisturizer if necessary. Even though my skin is very dry, I have not found any "top coat" to be necessary. It's nicely moisturizing. There is no discernible fragrance (it's light, pleasant, then gone - all good). My only complaint is the small size of the jar. Perhaps I'm applying it too liberally (I apply more than a dime-sized dab), but I expected to get a few more months out of it. I'm almost at the replenishment point. Despite the size, I will purchase it again. I am extremely happy with it.
You can purchase Acyl-Glutathione at Sephora and Nordstrom or directly from Perricone MD, where you can see instruction videos and will often find special offers.
Photo courtesy of Sephora